Ipamorelin

About Ipamorelin

Ipamorelin is a selective growth hormone secretagogue (GHS) and pentapeptide that specifically targets the ghrelin/growth hormone secretagogue receptor (GHS-R). As a highly selective research compound, Ipamorelin is studied for its ability to stimulate GH release without significantly affecting cortisol, prolactin, or other pituitary hormones, making it valuable for isolated GH pathway research.

Key Research Applications

GH Pathway Research: Ipamorelin is utilized in studies investigating growth hormone releasing mechanisms, pituitary gland function, somatotroph cell responses, and the relationship between GHS-R activation and pulse-pattern GH secretion in laboratory models.

Metabolic Studies: Research applications include investigating IGF-1 expression, protein synthesis pathways, lipolysis mechanisms, and glucose metabolism regulation through isolated GH receptor activation without confounding cortisol effects.

Bone Density Research: Laboratories employ Ipamorelin to study osteoblast activity, bone mineral density mechanisms, collagen synthesis in bone tissue, and calcium incorporation pathways in skeletal research models.

Muscle Tissue Research: The peptide is investigated for its effects on muscle protein synthesis, nitrogen retention, satellite cell activation, and myofibrillar protein accretion in cellular and tissue culture studies.

Mechanism of Action (Research Context)

Ipamorelin binds to and activates the GHS-R1a receptor (ghrelin receptor) on pituitary somatotrophs, triggering calcium mobilization and cAMP-dependent pathways that stimulate GH secretion. Research demonstrates its high selectivity with minimal desensitization of GH response, making it valuable for studying pulsatile GH release patterns without affecting ACTH or cortisol pathways.

Product Specifications

Form: Lyophilized sterile powder requiring reconstitution with bacteriostatic water for research applications.

Purity: Supplied at ≥98% purity (HPLC verified) for laboratory research use.

Storage: Store lyophilized powder at -20°C protected from light. After reconstitution, store at 2-8°C and use within 14 days.

Important: Ipamorelin is strictly for in-vitro laboratory research and scientific study only. NOT for human consumption or clinical use.