Semaglutide

About Semaglutide

Semaglutide is a synthetic peptide analog that functions as a GLP-1 (glucagon-like peptide-1) receptor agonist. As a research compound, Semaglutide is extensively studied in metabolic research laboratories for its interactions with incretin hormone pathways, glucose homeostasis mechanisms, and insulin secretion dynamics.

Key Research Applications

Metabolic Pathway Studies: Semaglutide is utilized in research investigating GLP-1 receptor activation and its downstream effects on glucose-dependent insulin secretion, glucagon suppression, and hepatic glucose production pathways.

Appetite Regulation Research: Laboratories use Semaglutide to study central nervous system mechanisms of satiety, including effects on hypothalamic appetite centers and gastric emptying rate modulation in research models.

Cardiovascular Research: Research applications include investigating potential cardioprotective mechanisms, endothelial function, blood pressure regulation, and inflammatory marker modulation in cellular and tissue studies.

Beta Cell Function: Semaglutide is employed in pancreatic research to study beta cell preservation, insulin biosynthesis pathways, and glucose-stimulated insulin secretion mechanisms in laboratory settings.

Mechanism of Action (Research Context)

In research models, Semaglutide demonstrates 94% homology to native human GLP-1 with modifications that extend its half-life. The peptide binds to GLP-1 receptors expressed in pancreatic islets, gastrointestinal tissue, and central nervous system structures, activating adenylyl cyclase and increasing intracellular cAMP levels in studied cell lines.

Product Specifications

Form: Lyophilized sterile powder requiring reconstitution with bacteriostatic water for research applications.

Purity: Supplied at ≥98% purity (HPLC verified) for laboratory research use only.

Storage: Store lyophilized powder at -20°C protected from light. After reconstitution, store at 2-8°C and use within 28 days for optimal stability in research protocols.

Important: Semaglutide is strictly for in-vitro laboratory research and scientific study only. NOT for human consumption, clinical use, or any in-vivo application outside approved research protocols.