Sermorelin

About Sermorelin

Sermorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH) consisting of 29 amino acids, used in GH research studies.

This research peptide is supplied as a lyophilized powder that requires reconstitution before use in laboratory applications. It is provided at research-grade purity for in-vitro studies only.

Research Applications: Sermorelin is used exclusively for laboratory research purposes. It is not intended for human consumption, medical treatment, or any form of in-vivo application.

Storage: Store lyophilized powder at -20°C. After reconstitution, store at 2-8°C and use within the timeframe specified by the manufacturer.

Detailed Research Information

Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH 1-29) studied in neuroendocrine and aging research laboratories. As a research compound, Sermorelin is investigated for its physiological growth hormone release patterns, pituitary function preservation, and age-related hormone decline mechanisms.

Key Research Applications

Physiological GH Research: Sermorelin is utilized in studies examining natural pulsatile growth hormone secretion patterns, circadian rhythm effects on GH release, and sleep-related hormone dynamics.

Pituitary Reserve Testing: Research applications include investigation of somatotroph cell functional capacity, pituitary gland integrity assessment protocols, and age-related pituitary function decline.

Aging Research: Sermorelin is employed in studies exploring somatopause mechanisms, age-related changes in GHRH receptor sensitivity, and interventions targeting declining growth hormone production.

Negative Feedback Studies: Research utilizes Sermorelin to investigate intact negative feedback mechanisms, somatostatin regulation of GH release, and physiological hormone regulation patterns.

Mechanism of Action

Sermorelin functions as a truncated form of endogenous GHRH, containing the first 29 amino acids which represent the fully functional domain for receptor activation. It binds to GHRH receptors on pituitary somatotrophs, activating adenylyl cyclase and increasing cAMP production. Research demonstrates that Sermorelin preserves physiological pulsatile GH secretion patterns and maintains negative feedback regulation through somatostatin, unlike exogenous GH administration which suppresses endogenous production.

Product Specifications

All listed research peptides are supplied in lyophilized (freeze-dried) powder form and require reconstitution with bacteriostatic water or sterile water before use in laboratory applications. Products are intended exclusively for in vitro research and are not for human consumption.