SS-31

About SS-31

SS-31, also known as Elamipretide, is a mitochondria-targeting peptide used in research studying mitochondrial function and cellular energy metabolism.

This research peptide is supplied as a lyophilized powder that requires reconstitution before use in laboratory applications. It is provided at research-grade purity for in-vitro studies only.

Research Applications: SS-31 is used exclusively for laboratory research purposes. It is not intended for human consumption, medical treatment, or any form of in-vivo application.

Storage: Store lyophilized powder at -20°C. After reconstitution, store at 2-8°C and use within the timeframe specified by the manufacturer.

Detailed Research Information

SS-31 (Elamipretide) is a synthetic tetrapeptide that selectively targets mitochondrial membranes, extensively studied in mitochondrial medicine and cellular bioenergetics research. As a research compound, SS-31 is investigated for its cardiolipin-binding properties, mitochondrial function optimization, and cellular energy production enhancement.

Key Research Applications

Mitochondrial Dysfunction Research: SS-31 is utilized in studies examining mitochondrial membrane potential stabilization, electron transport chain optimization, and ATP production efficiency in various cell models.

Cardiolipin Interaction Studies: Research applications include investigation of cardiolipin-cytochrome c interactions, inner mitochondrial membrane organization, and prevention of cardiolipin peroxidation.

Ischemia-Reperfusion Research: SS-31 is employed in studies exploring tissue protection during oxygen deprivation and restoration, examining mechanisms of reperfusion injury and cellular energy crisis.

Aging and Neurodegeneration: Research utilizes SS-31 to investigate mitochondrial dysfunction in aging models, neurodegenerative disease mechanisms, and mitochondrial-targeted therapeutic interventions.

Mechanism of Action

SS-31 functions through selective binding to cardiolipin, a phospholipid localized to the inner mitochondrial membrane that is essential for optimal electron transport chain function. The peptide contains alternating aromatic and basic residues that facilitate membrane permeability and cardiolipin recognition. Research demonstrates that SS-31 stabilizes cardiolipin-cytochrome c interactions, reduces reactive oxygen species production, prevents cytochrome c release, and optimizes ATP synthesis by improving electron transport chain efficiency.

Product Specifications

All listed research peptides are supplied in lyophilized (freeze-dried) powder form and require reconstitution with bacteriostatic water or sterile water before use in laboratory applications. Products are intended exclusively for in vitro research and are not for human consumption.