TB-500

About TB-500

TB-500 is a synthetic peptide fragment of Thymosin Beta-4, a naturally occurring 43-amino acid peptide. As a research compound, TB-500 is extensively studied in regenerative medicine research for its role in cellular migration, tissue repair mechanisms, wound healing pathways, and vascular development processes.

Key Research Applications

Tissue Repair Research: TB-500 is utilized in wound healing studies investigating cellular migration, extracellular matrix remodeling, collagen deposition, and tissue regeneration mechanisms in various tissue types including muscle, tendon, and connective tissue.

Angiogenesis Studies: Research laboratories employ TB-500 to study new blood vessel formation, endothelial cell proliferation, vascular endothelial growth factor (VEGF) interactions, and capillary network development in tissue culture models.

Anti-Inflammatory Research: The peptide is investigated for its effects on inflammatory cytokine modulation, including TNF-α and IL-1β pathways, and its role in resolving acute and chronic inflammatory responses in cellular systems.

Cellular Migration: TB-500 research focuses on actin regulation mechanisms, particularly its effects on G-actin sequestration and F-actin polymerization dynamics that facilitate cell motility and tissue remodeling processes.

Mechanism of Action (Research Context)

In laboratory studies, TB-500 binds to actin and promotes cell migration by preventing actin polymerization. This mechanism is studied for its role in facilitating stem cell migration to injury sites, promoting angiogenesis, and modulating inflammatory responses. Research also investigates its interaction with the PINCH-1-ILK-α-parvin (PIP) complex involved in cell adhesion and migration.

Product Specifications

Form: Lyophilized sterile powder requiring reconstitution with bacteriostatic water for research applications.

Purity: Supplied at ≥98% purity (HPLC verified) for laboratory research use.

Storage: Store lyophilized powder at -20°C protected from light. After reconstitution, store at 2-8°C for up to 14 days.

Important: TB-500 is strictly for in-vitro laboratory research and scientific study only. NOT for human consumption or clinical use.