IGF-1 DES

About IGF-1 DES

IGF-1 DES is a truncated form of insulin-like growth factor-1 used in research applications studying localized growth factor effects.

This research peptide is supplied as a lyophilized powder that requires reconstitution before use in laboratory applications. It is provided at research-grade purity for in-vitro studies only.

Research Applications: IGF-1 DES is used exclusively for laboratory research purposes. It is not intended for human consumption, medical treatment, or any form of in-vivo application.

Storage: Store lyophilized powder at -20°C. After reconstitution, store at 2-8°C and use within the timeframe specified by the manufacturer.

Detailed Research Information

IGF-1 DES (Des(1-3) Insulin-like Growth Factor-1) is a truncated variant of IGF-1 studied for its exceptional potency and localized tissue effects. As a research compound, IGF-1 DES is investigated for its enhanced receptor activation, minimal binding protein affinity, and site-specific growth factor signaling.

Key Research Applications

Localized Tissue Research: IGF-1 DES is utilized in studies examining autocrine and paracrine growth factor signaling, local tissue responses to IGF-1 stimulation, and site-specific cellular growth mechanisms.

Receptor Pharmacology: Research applications include investigation of IGF-1 receptor activation kinetics, receptor binding affinity measurements, and signal transduction pathway characterization.

Muscle Cell Studies: IGF-1 DES is employed in myoblast proliferation research, examining satellite cell activation mechanisms and muscle fiber hyperplasia in laboratory models.

Comparative IGF Studies: Research utilizes IGF-1 DES alongside native IGF-1 and IGF-1 LR3 to compare potency, duration of action, and tissue-specific responses across different IGF-1 variants.

Mechanism of Action

IGF-1 DES functions as a truncated form of IGF-1 lacking the first three N-terminal amino acids. This modification eliminates binding to all IGF binding proteins (IGFBPs) while increasing receptor affinity approximately 10-fold compared to native IGF-1. Research demonstrates that IGF-1 DES exhibits a very short half-life (approximately 20-30 minutes) but produces more potent localized effects due to enhanced receptor activation and absence of IGFBP sequestration, making it valuable for studying acute IGF-1 signaling events.

Product Specifications

All listed research peptides are supplied in lyophilized (freeze-dried) powder form and require reconstitution with bacteriostatic water or sterile water before use in laboratory applications. Products are intended exclusively for in vitro research and are not for human consumption.