PEG-MGF

About PEG-MGF

PEG-MGF (Pegylated Mechano Growth Factor) is a modified form of IGF-1 used in research studying tissue repair and growth mechanisms.

This research peptide is supplied as a lyophilized powder that requires reconstitution before use in laboratory applications. It is provided at research-grade purity for in-vitro studies only.

Research Applications: PEG-MGF is used exclusively for laboratory research purposes. It is not intended for human consumption, medical treatment, or any form of in-vivo application.

Storage: Store lyophilized powder at -20°C. After reconstitution, store at 2-8°C and use within the timeframe specified by the manufacturer.

Detailed Research Information

PEG-MGF (Pegylated Mechano Growth Factor) is a synthetic splice variant of insulin-like growth factor-1 studied in muscle physiology and tissue repair research. As a research compound, PEG-MGF is investigated for its role in mechanotransduction, satellite cell activation, and muscle tissue regeneration mechanisms.

Key Research Applications

Muscle Regeneration Research: PEG-MGF is utilized in studies examining satellite cell recruitment mechanisms, myoblast proliferation pathways, and muscle fiber repair processes following mechanical stress.

Mechanotransduction Studies: Research applications include investigation of mechanical load-induced growth factor expression, stretch-activated signaling cascades, and exercise-induced muscle adaptation mechanisms.

Neuroprotection Research: PEG-MGF is employed in studies exploring neuron survival pathways, neuroplasticity mechanisms, and neuroprotective growth factor signaling in nervous tissue models.

Splice Variant Studies: Research utilizes PEG-MGF to compare MGF splice variant effects versus systemic IGF-1, examining tissue-specific responses and differential receptor activation patterns.

Mechanism of Action

PEG-MGF functions as a C-terminal splice variant of IGF-1 that is expressed locally in response to mechanical stimulation of muscle tissue. The PEGylation modification extends the half-life from minutes to hours by increasing molecular weight and reducing renal clearance. Research demonstrates that MGF activates satellite cells through IGF-1 receptor-independent mechanisms in addition to standard IGF-1R signaling, and the unique C-terminal E-domain peptide may contribute to distinct biological activities not observed with systemic IGF-1.

Product Specifications

All listed research peptides are supplied in lyophilized (freeze-dried) powder form and require reconstitution with bacteriostatic water or sterile water before use in laboratory applications. Products are intended exclusively for in vitro research and are not for human consumption.