P21

About P21

P21 is a synthetic peptide used in research studying cognitive enhancement, neuroplasticity, and dendrite formation.

This research peptide is supplied as a lyophilized powder that requires reconstitution before use in laboratory applications. It is provided at research-grade purity for in-vitro studies only.

Research Applications: P21 is used exclusively for laboratory research purposes. It is not intended for human consumption, medical treatment, or any form of in-vivo application.

Storage: Store lyophilized powder at -20°C. After reconstitution, store at 2-8°C and use within the timeframe specified by the manufacturer.

Detailed Research Information

P21 is a synthetic peptide derived from ciliary neurotrophic factor (CNTF), extensively studied in neuroscience and metabolic research. As a research compound, P21 is investigated for its neuroprotective properties, metabolic regulation effects, and receptor signaling mechanisms.

Key Research Applications

Neuroprotection Research: P21 is utilized in studies examining neuronal survival mechanisms, investigating protective effects against oxidative stress, excitotoxicity, and apoptotic pathways in neuronal culture models.

Metabolic Research: Research applications include investigation of leptin receptor pathway activation, examining effects on energy homeostasis, appetite regulation, and metabolic parameter modulation.

Neuroinflammation Studies: P21 is employed in studies exploring anti-inflammatory mechanisms in central nervous system models, examining microglial activation and inflammatory cytokine production.

Receptor Pharmacology: Research utilizes P21 to investigate CNTF receptor complex activation, examining gp130 signaling, JAK-STAT pathway activation, and neuroprotective signal transduction.

Mechanism of Action

P21 functions as a small molecule mimetic of CNTF, activating the CNTF receptor complex which includes CNTFRalpha, gp130, and LIFRbeta subunits. This activation triggers JAK-STAT signaling pathways, particularly STAT3 phosphorylation, leading to neuroprotective gene expression. Research demonstrates that P21 provides neuroprotection through multiple mechanisms including enhancement of antioxidant defenses, reduction of pro-apoptotic signaling, and modulation of inflammatory responses, while also influencing metabolic pathways through leptin receptor-related signaling.

Product Specifications

All listed research peptides are supplied in lyophilized (freeze-dried) powder form and require reconstitution with bacteriostatic water or sterile water before use in laboratory applications. Products are intended exclusively for in vitro research and are not for human consumption.