PT-141

About PT-141

PT-141, also known as Bremelanotide, is a synthetic peptide used in research studying melanocortin receptor pathways and neurological signaling.

This research peptide is supplied as a lyophilized powder that requires reconstitution before use in laboratory applications. It is provided at research-grade purity for in-vitro studies only.

Research Applications: PT-141 is used exclusively for laboratory research purposes. It is not intended for human consumption, medical treatment, or any form of in-vivo application.

Storage: Store lyophilized powder at -20°C. After reconstitution, store at 2-8°C and use within the timeframe specified by the manufacturer.

Detailed Research Information

PT-141 (Bremelanotide) is a synthetic peptide analog of alpha-melanocyte stimulating hormone studied in neuroscience and behavioral research. As a research compound, PT-141 is investigated for its effects on melanocortin receptor signaling, particularly MC4R and MC3R pathways in central nervous system function.

Key Research Applications

MC4R Signaling Research: PT-141 is utilized in studies examining melanocortin-4 receptor activation in central nervous system pathways, investigating receptor-mediated behavioral and physiological responses.

Neurobehavioral Research: Research applications include investigation of hypothalamic melanocortin circuits, examining neural pathways involved in motivation, reward processing, and behavioral regulation.

Receptor Pharmacology Studies: PT-141 is employed in studies mapping melanocortin receptor distribution, examining receptor selectivity, binding kinetics, and signal transduction mechanisms.

Comparative Melanocortin Studies: Research utilizes PT-141 alongside other melanocortin agonists to investigate structure-activity relationships, receptor subtype selectivity, and differential physiological effects.

Mechanism of Action

PT-141 functions primarily through activation of melanocortin-4 receptors (MC4R) and melanocortin-3 receptors (MC3R) in the central nervous system, particularly in hypothalamic and limbic regions. The peptide is a metabolite of Melanotan-2 with enhanced selectivity for central melanocortin receptors. Research demonstrates that PT-141 activates G-protein coupled receptor signaling cascades, increasing intracellular cAMP and activating downstream pathways including MAPK/ERK and PI3K/Akt, which modulate neuronal excitability and neurotransmitter release in melanocortin-expressing neural circuits.

Product Specifications

All listed research peptides are supplied in lyophilized (freeze-dried) powder form and require reconstitution with bacteriostatic water or sterile water before use in laboratory applications. Products are intended exclusively for in vitro research and are not for human consumption.